PF3D7_1004200

Genome location: Pf3D7_10_v3:187,192..196,990(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Component	GO:0071011	precatalytic spliceosome
Process	GO:0008380	RNA splicing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.45	0.79
Trophozoite	expressed	1.55	0.33
Schizont	expressed	1.55	0.41
Gametocyte	expressed	0.98	0.50

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1004200

Resistome Missense Mutations: L1271F

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.193 | MFS: -2.75 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1202500)

Relative Growth Rate: 0.18 ± 0.09
Confidence: 6.15

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_133041

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	38	159	104	204
disruptive	160	440	278	553
missense	106	383	233	467

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	71	344	145	235
disruptive	255	944	424	808
missense	161	775	333	591

PlasmoDB Total SNPs: 409

Non-coding: 94 | Synonymous: 186 | Nonsynonymous: 129 | Stop Codon: 0

Protein Information

Protein Length: 3013 | Molecular Weight (kDa): 358.077

UniProt ID(s): Q8IJZ5

PDB ID(s): None

Isoelectric Point: 9.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094