About Gene List

PF3D7_1004400

Genome location: Pf3D7_10_v3:206,616..210,233(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus
Component GO:1990904 ribonucleoprotein complex
Function GO:0003729 mRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.20 0.91
Trophozoite expressed 0.81 0.57
Schizont expressed 0.17 0.88
Gametocyte expressed 0.52 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1004400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.992 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJZ3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101955

Most Similar Human Ortholog: G3V5K8

TM-align score: 0.73 | RMSD: 2.16

Seq Identity: 0.28 | Length: 83 / 880

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000100650 serine and arginine rich splicing factor 5
ENSG00000116350 serine and arginine rich splicing factor 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 54 38 72
disruptive 35 163 88 221
missense 24 142 76 195

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 106 53 82
disruptive 70 353 133 290
missense 44 306 118 201

PlasmoDB Total SNPs: 120

Non-coding: 62 | Synonymous: 35 | Nonsynonymous: 23 | Stop Codon: 0

Protein Information

Protein Length: 880 | Molecular Weight (kDa): 106.298

UniProt ID(s): Q8IJZ3

PDB ID(s): None

Isoelectric Point: 9.04

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000504 RNA recognition motif domain
InterPro IPR035979 RNA-binding domain superfamily
PFam PF00076 RNA recognition motif domain
Superfamily SSF54928 RNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
27381095 The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. Bunnik EM, Batugedara G, ..., Le Roch KG 10.1186/s13059-016-1014-0