Product Description: apicomplexan kinetochore protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0000776 | kinetochore |
Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.05 | 0.97 |
Trophozoite | not expressed | 0.30 | 0.81 |
Schizont | expressed | 0.31 | 0.79 |
Gametocyte | not expressed | 0.32 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1004500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.613 | MFS: -3.599 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1202800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1202800)
Modification: Tagged | RMgm-5114
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJZ2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 2 | 10 | 3 | 15 |
disruptive | 2 | 8 | 11 | 18 |
missense | 2 | 8 | 11 | 14 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 2 | 21 | 9 | 17 |
disruptive | 4 | 26 | 18 | 40 |
missense | 4 | 21 | 16 | 30 |
PlasmoDB Total SNPs: 227
Non-coding: 216 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 202 | Molecular Weight (kDa): 24.26
UniProt ID(s): Q8IJZ2
PDB ID(s): None
Isoelectric Point: 4.75
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
36006241 | Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation | Brusini L, Dos Santos Pacheco N, ..., Brochet M | 10.1083/jcb.202111084 |