About Gene List

PF3D7_1004600

Genome location: Pf3D7_10_v3:215,344..219,759(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 12

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite not expressed 0.45 0.75
Schizont expressed 1.04 0.47
Gametocyte not expressed 0.43 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1004600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.628 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1202900)

Modification: Disrupted | RMgm-3178

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJZ1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533119

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 70 35 93
disruptive 35 110 79 236
missense 30 101 71 200

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 22 136 46 82
disruptive 60 264 152 302
missense 44 219 128 216

PlasmoDB Total SNPs: 269

Non-coding: 153 | Synonymous: 66 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 1079 | Molecular Weight (kDa): 130.105

UniProt ID(s): Q8IJZ1

PDB ID(s): None

Isoelectric Point: 9.95

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097