PF3D7_1004700

Genome location: Pf3D7_10_v3:219,826..221,789(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	possibly expressed	0.10	0.93
Schizont	possibly expressed	0.05	0.96
Gametocyte	expressed	0.24	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1004700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.93 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJZ0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160736

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	18	8	19
disruptive	3	16	19	37
missense	3	16	19	36

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	32	13	22
disruptive	7	47	34	69
missense	7	42	30	54

PlasmoDB Total SNPs: 148

Non-coding: 132 | Synonymous: 13 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 267 | Molecular Weight (kDa): 31.613

UniProt ID(s): Q8IJZ0

PDB ID(s): None

Isoelectric Point: 9.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A