PF3D7_1004800 (AAC2)

Genome location: Pf3D7_10_v3:221,826..223,568(+)

Genome classification: Core

Function and Localization

Product Description: ADP,ATP carrier protein 2

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005743	mitochondrial inner membrane
Component	GO:0005739	mitochondrion
Function	GO:0005471	ATP:ADP antiporter activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.03	0.99
Trophozoite	expressed	0.21	0.86
Schizont	expressed	0.10	0.93
Gametocyte	expressed	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1004800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.156 | MFS: -2.921 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1203100)

Relative Growth Rate: 0.31 ± 0.25
Confidence: 4.16

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJY9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156442

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	20	10	30
disruptive	10	45	25	50
missense	10	42	25	42

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	34	14	45
disruptive	22	86	38	79
missense	18	80	35	55

PlasmoDB Total SNPs: 122

Non-coding: 89 | Synonymous: 14 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 340 | Molecular Weight (kDa): 41.01

UniProt ID(s): Q8IJY9

PDB ID(s): None

Isoelectric Point: 10.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002067	Mitochondrial carrier protein
InterPro	IPR018108	Mitochondrial substrate/solute carrier
InterPro	IPR023395	Mitochondrial carrier domain superfamily
PFam	PF00153	Mitochondrial substrate/solute carrier
Superfamily	SSF103506	Mitochondrial carrier domain superfamily

Associated Publications

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
32574727	Characterization of mitochondrial carrier proteins of malaria parasite Plasmodiumfalciparum based on in vitro translation and reconstitution.	Nozawa A, Ito D, ..., Tozawa Y	10.1016/j.parint.2020.102160
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21
33923309	A Yeast-Based Screening Unravels Potential Therapeutic Molecules forMitochondrial Diseases Associated with Dominant ANT1 Mutations	di Punzio G, Di Noia MA, ..., Dallabona C	10.3390/ijms22094461
34946817	Saccharomyces cerevisiae as a Tool for Studying Mutations in Nuclear GenesInvolved in Diseases Caused by Mitochondrial DNA Instability	Gilea AI, Ceccatelli Berti C, ..., Dallabona C	10.3390/genes12121866
34320205	Utilization of ethanol for itaconic acid biosynthesis by engineered Saccharomycescerevisiae	Xu Y, Li Z	10.1093/femsyr/foab043