About Gene List

PF3D7_1004900

Genome location: Pf3D7_10_v3:224,040..225,383(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.07 0.96
Trophozoite expressed 0.61 0.65
Schizont expressed 0.24 0.85
Gametocyte expressed 0.74 0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1004900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -2.977 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1203200)

Modification: Tagged | RMgm-4967

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJY8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_137236

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 11 19 17
disruptive 7 25 11 40
missense 7 25 11 37

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 32 15 26
disruptive 10 60 23 62
missense 10 54 20 50

PlasmoDB Total SNPs: 67

Non-coding: 48 | Synonymous: 13 | Nonsynonymous: 5 | Stop Codon: 1

Protein Information

Protein Length: 319 | Molecular Weight (kDa): 38.863

UniProt ID(s): Q8IJY8

PDB ID(s): None

Isoelectric Point: 10.31

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21