Product Description: U3 small nucleolar RNA-associated protein 25, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Component | GO:0032040 | small-subunit processome |
| Function | GO:0034511 | U3 snoRNA binding |
| Function | GO:0019843 | rRNA binding |
| Process | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0042274 | ribosomal small subunit biogenesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.79 | 0.65 |
| Trophozoite | expressed | 0.55 | 0.70 |
| Schizont | not expressed | 0.16 | 0.90 |
| Gametocyte | expressed | 0.52 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1005100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.128 | MFS: -3.14 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJY7
"Best" AlphaFill ligand hit: GST (geranyl s-thiolodiphosphate, Local RMSD=0.64) with 6VL0 (Global RMSD=16.07)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102630
Most Similar Human Ortholog: Q68CQ4
TM-align score: 0.69 | RMSD: 3.33
Seq Identity: 0.25 | Length: 561 / 1131
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000117597 | UTP25 small subunit processor component |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 47 | 33 | 83 |
| disruptive | 62 | 178 | 105 | 272 |
| missense | 42 | 151 | 95 | 237 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 121 | 51 | 101 |
| disruptive | 121 | 432 | 166 | 368 |
| missense | 66 | 360 | 140 | 268 |
PlasmoDB Total SNPs: 174
Non-coding: 55 | Synonymous: 57 | Nonsynonymous: 53 | Stop Codon: 9
Protein Length: 1131 | Molecular Weight (kDa): 135.114
UniProt ID(s): Q8IJY7
PDB ID(s): None
Isoelectric Point: 9.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010678 | Digestive organ expansion factor, predicted |
| PFam | PF06862 | Digestive organ expansion factor, predicted |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20528918 | Utp25p, a nucleolar Saccharomyces cerevisiae protein, interacts with U3 snoRNPsubunits and affects processing of the 35S pre-rRNA | Goldfeder MB, Oliveira CC | 10.1111/j.1742-4658.2010.07701.x |
| 21941128 | The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p andis essential for the production of the 40S ribosomal subunit in Saccharomycescerevisiae | Choque E, Marcellin M, ..., Dez C | 10.4161/rna.8.6.17699 |