PF3D7_1005300

Genome location: Pf3D7_10_v3:233,285..234,473(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.12	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1005300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.831 | MFS: -2.329 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJY6

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=0.06) with 2BVL (Global RMSD=10.82)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533560

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	12	12	26
disruptive	9	36	20	67
missense	7	35	20	63

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	27	18	20
disruptive	15	80	44	91
missense	12	74	42	72

PlasmoDB Total SNPs: 50

Non-coding: 9 | Synonymous: 23 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 343 | Molecular Weight (kDa): 41.356

UniProt ID(s): Q8IJY6

PDB ID(s): None

Isoelectric Point: 9.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A