PF3D7_1005400

Genome location: Pf3D7_10_v3:234,795..235,745(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	possibly expressed	0.01	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1005400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.164 | MFS: -2.635 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1203600)

Relative Growth Rate: 1.05 ± 0.16
Confidence: 5.05

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1203600)

Modification: Disrupted | RMgm-3180

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJY5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532848

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	15	6	22
disruptive	12	44	26	54
missense	12	44	25	51

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	32	15	17
disruptive	18	104	31	59
missense	16	95	31	45

PlasmoDB Total SNPs: 66

Non-coding: 38 | Synonymous: 19 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 266 | Molecular Weight (kDa): 31.867

UniProt ID(s): Q8IJY5

PDB ID(s): None

Isoelectric Point: 10.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094