Product Description: peptidase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0004222 | metalloendopeptidase activity |
| Process | GO:0006518 | peptide metabolic process |
| Process | GO:0006508 | proteolysis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.17 | 0.89 |
| Schizont | expressed | 0.38 | 0.77 |
| Gametocyte | expressed | 0.21 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1005700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -2.998 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1203900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJY3
"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=7.95) with 2W5Y (Global RMSD=20.16)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100561
Most Similar Human Ortholog: K7EP46
TM-align score: 0.76 | RMSD: 4.51
Seq Identity: 0.13 | Length: 523 / 772
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000123213 | neurolysin |
| ENSG00000172009 | thimet oligopeptidase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 44 | 25 | 54 |
| disruptive | 43 | 121 | 79 | 146 |
| missense | 30 | 99 | 66 | 117 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 84 | 43 | 54 |
| disruptive | 75 | 249 | 118 | 212 |
| missense | 47 | 193 | 103 | 139 |
PlasmoDB Total SNPs: 245
Non-coding: 151 | Synonymous: 44 | Nonsynonymous: 50 | Stop Codon: 0
Protein Length: 772 | Molecular Weight (kDa): 93.974
UniProt ID(s): Q8IJY3
PDB ID(s): None
Isoelectric Point: 9.69
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001567 | Peptidase M3A/M3B catalytic domain |
| InterPro | IPR033851 | Mitochondrial intermediate peptidase |
| PFam | PF01432 | Peptidase M3A/M3B catalytic domain |
| Superfamily | SSF55486 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |