PF3D7_1005800

Genome location: Pf3D7_10_v3:250,971..252,615(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.06	0.95
Gametocyte	not expressed	0.01	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1005800

Resistome Missense Mutations: F141L

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.08 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1204000)

Relative Growth Rate: 0.84 ± 0.20
Confidence: 4.64

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1204000)

Modification: Disrupted | RMgm-3183

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJY2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532876

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	8	3	13
disruptive	1	12	15	16
missense	1	12	14	15

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	17	8	21
disruptive	5	44	17	35
missense	2	37	14	24

PlasmoDB Total SNPs: 161

Non-coding: 148 | Synonymous: 8 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 226 | Molecular Weight (kDa): 27.458

UniProt ID(s): Q8IJY2

PDB ID(s): None

Isoelectric Point: 9.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A