About Gene List

PF3D7_1005900

Genome location: Pf3D7_10_v3:253,544..255,931(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MILWNKKLLSVVFLLIYDTTNC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.98
Trophozoite possibly expressed 0.42 0.75
Schizont possibly expressed 0.39 0.77
Gametocyte expressed 0.92 0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1005900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.898 | MFS: -2.259 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1204100)

  • Relative Growth Rate: 0.09 ± 0.05
  • Confidence: 7.57

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJY1

"Best" AlphaFill ligand hit: APC (alpha,beta-methyleneadenosine-5'-triphosphate, Local RMSD=7.36) with 6E0L (Global RMSD=28.39)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139480

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 40 28 49
disruptive 4 56 23 81
missense 4 54 23 74

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 79 24 48
disruptive 23 116 65 116
missense 13 99 55 88

PlasmoDB Total SNPs: 70

Non-coding: 32 | Synonymous: 30 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 635 | Molecular Weight (kDa): 76.474

UniProt ID(s): Q8IJY1

PDB ID(s): None

Isoelectric Point: 9.59

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895