PF3D7_1006000 (IMP4)

Genome location: Pf3D7_10_v3:255,990..258,116(-)

Genome classification: Core

Function and Localization

Product Description: IMP1-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.09	0.96
Trophozoite	possibly expressed	0.03	0.98
Schizont	possibly expressed	0.04	0.98
Gametocyte	expressed	1.02	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1006000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.453 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1204200)

Relative Growth Rate: 0.88 ± 0.16
Confidence: 4.99

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1204200)

Modification: Disrupted | RMgm-3185

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJY0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146154

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	17	20	35
disruptive	12	53	45	80
missense	7	43	35	65

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	52	17	43
disruptive	26	126	47	107
missense	12	98	38	75

PlasmoDB Total SNPs: 152

Non-coding: 99 | Synonymous: 45 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 426 | Molecular Weight (kDa): 50.254

UniProt ID(s): Q8IJY0

PDB ID(s): None

Isoelectric Point: 8.1

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR040955	Immune mapped protein 2, N-terminal
PFam	PF18590	Immune mapped protein 2, N-terminal
Superfamily	N/A	N/A