Product Description: DNA/RNA-binding protein Alba 3
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0036396 | RNA N6-methyladenosine methyltransferase complex |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0020020 | food vacuole |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Function | GO:0003723 | RNA binding |
| Function | GO:0004519 | endonuclease activity |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.75 | 0.65 |
| Trophozoite | expressed | 1.00 | 0.49 |
| Schizont | expressed | 0.28 | 0.82 |
| Gametocyte | expressed | 0.36 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1006200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1204400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1204400)
Modification: Disrupted | RMgm-3186
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJX8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 1 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 2 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 294
Non-coding: 276 | Synonymous: 18 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 107 | Molecular Weight (kDa): 11.977
UniProt ID(s): Q8IJX8
PDB ID(s): None
Isoelectric Point: 9.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002775 | DNA/RNA-binding protein Alba-like |
| InterPro | IPR014560 | Uncharacterised conserved protein UCP030333, DNA/RNA-binding Alba-related |
| InterPro | IPR036882 | Alba-like domain superfamily |
| PFam | PF01918 | DNA/RNA-binding protein Alba-like |
| Superfamily | SSF82704 | Alba-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 22006844 | Identification and molecular characterization of an Alba-family protein fromhuman malaria parasite Plasmodium falciparum. | Goyal M, Alam A, ..., Bandyopadhyay U | 10.1093/nar/gkr821 |
| 22167473 | PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malariaparasites. | Chene A, Vembar SS, ..., Scherf A | 10.1093/nar/gkr1215 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31384004 | Transcriptome-wide dynamics of extensive m(6)A mRNA methylation during Plasmodiumfalciparum blood-stage development. | Baumgarten S, Bryant JM, ..., Scherf A | 10.1038/s41564-019-0521-7 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 21811616 | Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteinsthat interact with the translation machinery | Mani J, Guttinger A, ..., Roditi I | 10.1371/journal.pone.0022463 |
| 30146924 | Assessing the partners of the RBP9-mRNP complex in Trypanosoma cruzi usingshotgun proteomics and RNA-seq | Wippel HH, Inoue AH, ..., Alves LR | 10.1080/15476286.2018.1509660 |
| 38148574 | The Plasmodium falciparum CCCH zinc finger protein MD3 regulates malegametocytogenesis through its interaction with RNA-binding proteins | Farrukh A, Musabyimana JP, ..., Ngwa CJ | 10.1111/mmi.15215 |
| 36947546 | Nuclease activity of Plasmodium falciparum Alba family protein PfAlba3 | Banerjee C, Nag S, ..., Bandyopadhyay U | 10.1016/j.celrep.2023.112292 |
| 31185899 | Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi andortholog to the yeast SR-protein Gbp2 | Wippel HH, Malgarin JS, ..., Alves LR | 10.1186/s12866-019-1505-8 |
| 33960872 | The RNA structurome in the asexual blood stages of malaria pathogen plasmodiumfalciparum | Alvarez DR, Ospina A, ..., Chakrabarti K | 10.1080/15476286.2021.1926747 |
| 33493187 | An Alba-domain protein required for proteome remodelling during trypanosomedifferentiation and host transition | Bevkal S, Naguleswaran A, ..., Roditi I | 10.1371/journal.ppat.1009239 |
| 21965287 | ALBA proteins are stage regulated during trypanosome development in the tsetsefly and participate in differentiation | Subota I, Rotureau B, ..., Bastin P | 10.1091/mbc.E11-06-0511 |