PF3D7_1006300

Genome location: Pf3D7_10_v3:265,750..266,836(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MNNHMGVLFLFILFLYKTYD

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.01	1.00
Schizont	no data	0.00	1.00
Gametocyte	no data	0.59	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1006300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.13 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZX62

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533738

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	4	10
disruptive	1	18	6	21
missense	1	18	5	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	15	8	12
disruptive	6	47	13	41
missense	5	37	13	20

PlasmoDB Total SNPs: 121

Non-coding: 109 | Synonymous: 6 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 143 | Molecular Weight (kDa): 17.177

UniProt ID(s): A0A143ZX62

PDB ID(s): None

Isoelectric Point: 6.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A