PF3D7_1006400

Genome location: Pf3D7_10_v3:266,941..269,894(-)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.06	0.97
Trophozoite	possibly expressed	0.19	0.88
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.35	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1006400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.173 | MFS: -2.741 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1204600)

Modification: Other | RMgm-415

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJX7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532454

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	53	26	66
disruptive	10	96	58	129
missense	10	94	58	114

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	92	37	85
disruptive	24	193	119	202
missense	22	178	108	155

PlasmoDB Total SNPs: 94

Non-coding: 30 | Synonymous: 51 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 870 | Molecular Weight (kDa): 103.335

UniProt ID(s): Q8IJX7

PDB ID(s): None

Isoelectric Point: 7.19

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	PF08373	RAP domain
Superfamily	N/A	N/A