About Gene List

PF3D7_1006600 (PhLP3)

Genome location: Pf3D7_10_v3:272,223..273,497(-)

Genome classification: Core

Function and Localization

Product Description: phosducin-like protein 3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Function GO:0016491 oxidoreductase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.17 0.92
Trophozoite expressed 0.63 0.65
Schizont not expressed 0.15 0.90
Gametocyte expressed 0.88 0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1006600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.134 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0519700)

  • Relative Growth Rate: 0.99 ± 0.10
  • Confidence: 5.94

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJX5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101215

Most Similar Human Ortholog: O14530

TM-align score: 0.74 | RMSD: 1.88

Seq Identity: 0.45 | Length: 152 / 193

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000115514 thioredoxin domain containing 9

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 9 3 11
disruptive 1 3 2 14
missense 1 3 2 13

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 20 8 8
disruptive 1 17 13 39
missense 1 12 10 24

PlasmoDB Total SNPs: 61

Non-coding: 56 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 193 | Molecular Weight (kDa): 23.19

UniProt ID(s): Q8IJX5

PDB ID(s): None

Isoelectric Point: 7.95

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013766 Thioredoxin domain
InterPro IPR036249 Thioredoxin-like superfamily
PFam PF00085 Thioredoxin domain
Superfamily SSF52833 Thioredoxin-like superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30596727 Characterization of a protozoan Phosducin-like protein-3 (PhLP-3) revealsconserved redox activity. Kooistra RL, David R, ..., Kanzok SM 10.1371/journal.pone.0209699
22995278 The evolution and putative function of phosducin-like proteins in the malariaparasite Plasmodium Putonti C, Quach B, Kooistra RL, Kanzok SM 10.1016/j.meegid.2012.08.023