PF3D7_1006700

Genome location: Pf3D7_10_v3:273,590..275,557(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.81	0.63
Trophozoite	expressed	0.73	0.64
Schizont	expressed	0.19	0.89
Gametocyte	expressed	1.21	0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1006700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 5 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.458 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJX4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533120

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	19	15	18
disruptive	14	38	15	59
missense	5	23	15	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	42	14	20
disruptive	31	70	43	82
missense	9	57	35	56

PlasmoDB Total SNPs: 161

Non-coding: 94 | Synonymous: 49 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 383 | Molecular Weight (kDa): 45.624

UniProt ID(s): Q8IJX4

PDB ID(s): None

Isoelectric Point: 7.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009563	Sjoegren syndrome/scleroderma autoantigen 1
PFam	PF06677	Sjoegren syndrome/scleroderma autoantigen 1
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108