Product Description: G-strand-binding protein 2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0020020 | food vacuole |
| Component | GO:0005634 | nucleus |
| Component | GO:1990904 | ribonucleoprotein complex |
| Function | GO:0051880 | G-quadruplex DNA binding |
| Function | GO:0098505 | G-rich strand telomeric DNA binding |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0042162 | telomeric DNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.24 | 0.47 |
| Trophozoite | expressed | 1.21 | 0.42 |
| Schizont | expressed | 0.25 | 0.85 |
| Gametocyte | expressed | 0.59 | 0.68 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1006800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.462 | MFS: -2.479 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1205000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1205000)
Modification: Tagged | RMgm-5086
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJX3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103495
Most Similar Human Ortholog: A0A087WUT0
TM-align score: 0.42 | RMSD: 5.03
Seq Identity: 0.24 | Length: 147 / 246
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000104177 | myelin expression factor 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 193
Non-coding: 179 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 246 | Molecular Weight (kDa): 29.53
UniProt ID(s): Q8IJX3
PDB ID(s): None
Isoelectric Point: 9.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33340385 | PfGBP2 is a novel G-quadruplex binding protein in Plasmodium falciparum. | Gurung P, Gomes AR, ..., Lopez-Rubio JJ | 10.1111/cmi.13303 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 34604117 | Roles and Cellular Localization of GBP2 and NAB2 During the Blood Stage ofMalaria Parasites. | Niikura M, Fukutomi T, Mitobe J, Kobayashi F | 10.3389/fcimb.2021.737457 |
| 35273922 | Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds toG-Quadruplex DNA and RNA. | Edwards-Smallbone J, Jensen AL, ..., Merrick CJ | 10.3389/fcimb.2022.782537 |