PF3D7_1006900

Genome location: Pf3D7_10_v3:281,002..283,515(+)

Genome classification: Core

Function and Localization

Product Description: PPPDE peptidase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0101005	deubiquitinase activity
Process	GO:0016579	protein deubiquitination
Process	GO:0070646	protein modification by small protein removal

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.06	0.97
Trophozoite	expressed	0.17	0.89
Schizont	expressed	0.05	0.96
Gametocyte	expressed	0.57	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1006900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.178 | MFS: -2.731 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0820100)

Relative Growth Rate: 1.02 ± 0.07
Confidence: 6.63

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJX2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101256

Most Similar Human Ortholog: B1APK7

TM-align score: 0.67 | RMSD: 2.51

Seq Identity: 0.22 | Length: 82 / 219

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000121644	desumoylating isopeptidase 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	6	4	7
disruptive	7	4	19
missense	6	4	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	15	11	20
disruptive	2	20	27	50
missense	1	15	25	42

PlasmoDB Total SNPs: 170

Non-coding: 151 | Synonymous: 17 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 219 | Molecular Weight (kDa): 24.94

UniProt ID(s): Q8IJX2

PDB ID(s): None

Isoelectric Point: 4.68

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008580	PPPDE peptidase domain
PFam	PF05903	PPPDE peptidase domain
Superfamily	N/A	N/A