Genome location: Pf3D7_10_v3:283,801..286,957(+)
Genome classification: Core
Product Description: transmembrane protein 147, putative
SignalP Peptide: N/A
# Transmembrane Domains: 6
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016020 | membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.31 | 0.80 |
| Schizont | expressed | 0.09 | 0.93 |
| Gametocyte | expressed | 0.27 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1007000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.198 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1205200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1205200)
Modification: Disrupted | RMgm-3188
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJX1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105654
Most Similar Human Ortholog: Q9BVK8
TM-align score: 0.87 | RMSD: 2.47
Seq Identity: 0.23 | Length: 222 / 260
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105677 | transmembrane protein 147 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 20 | 9 | 19 |
| disruptive | 1 | 30 | 17 | 26 |
| missense | 1 | 30 | 16 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 40 | 14 | 17 |
| disruptive | 8 | 54 | 26 | 51 |
| missense | 5 | 47 | 24 | 39 |
PlasmoDB Total SNPs: 235
Non-coding: 223 | Synonymous: 10 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 260 | Molecular Weight (kDa): 30.15
UniProt ID(s): Q8IJX1
PDB ID(s): None
Isoelectric Point: 9.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019164 | Transmembrane protein 147 |
| PFam | PF09767 | Transmembrane protein 147 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |