PF3D7_1007100

Genome location: Pf3D7_10_v3:286,522..287,473(-)

Genome classification: Core

Function and Localization

Product Description: roadblock/LC7 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005868	cytoplasmic dynein complex
Function	GO:0045505	dynein intermediate chain binding
Process	GO:0007018	microtubule-based movement

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.04	0.97
Schizont	no data	0.03	0.98
Gametocyte	no data	0.19	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1007100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.996 | MFS: -0.261 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1205300)

Relative Growth Rate: 0.94 ± 0.11
Confidence: 5.89

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1205300)

Modification: Disrupted | RMgm-3189

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3C4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109877

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	9	3	4
disruptive	1	9	3	12
missense	1	9	3	11

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	14	5	5
disruptive	5	16	10	25
missense	3	13	9	22

PlasmoDB Total SNPs: 84

Non-coding: 81 | Synonymous: 1 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 116 | Molecular Weight (kDa): 13.282

UniProt ID(s): C6S3C4

PDB ID(s): None

Isoelectric Point: 8.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004942	Roadblock/LAMTOR2 domain
PFam	PF03259	Roadblock/LAMTOR2 domain
Superfamily	SSF103196	N/A