Product Description: rho GTPase-activating protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0005096 | GTPase activator activity |
| Process | GO:0007266 | Rho protein signal transduction |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.16 | 0.89 |
| Schizont | expressed | 0.93 | 0.50 |
| Gametocyte | expressed | 0.32 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1007200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.15 | MFS: -2.751 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1205400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1205400)
Modification: Disrupted | RMgm-3190
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJX0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103505
Most Similar Human Ortholog: B1AHC2
TM-align score: 0.77 | RMSD: 2.25
Seq Identity: 0.30 | Length: 102 / 593
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000175220 | Rho GTPase activating protein 1 |
| ENSG00000241484 | Rho GTPase activating protein 8 |
| ENSG00000248405 | PRR5-ARHGAP8 readthrough |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 26 | 10 | 38 |
| disruptive | 8 | 36 | 15 | 41 |
| missense | 5 | 33 | 15 | 34 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 54 | 27 | 30 |
| disruptive | 14 | 75 | 40 | 113 |
| missense | 9 | 60 | 30 | 79 |
PlasmoDB Total SNPs: 281
Non-coding: 220 | Synonymous: 31 | Nonsynonymous: 30 | Stop Codon: 0
Protein Length: 593 | Molecular Weight (kDa): 67.448
PDB ID(s): None
Isoelectric Point: 5.07
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000198 | Rho GTPase-activating protein domain |
| InterPro | IPR001251 | CRAL-TRIO lipid binding domain |
| InterPro | IPR008936 | Rho GTPase activation protein |
| InterPro | IPR036865 | CRAL-TRIO lipid binding domain superfamily |
| PFam | PF00620 | Rho GTPase-activating protein domain |
| PFam | PF13716 | CRAL-TRIO lipid binding domain |
| Superfamily | SSF48350 | Rho GTPase activation protein |
| Superfamily | SSF52087 | CRAL-TRIO lipid binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |