PF3D7_1007300

Genome location: Pf3D7_10_v3:292,725..296,323(+)

Genome classification: Core

Function and Localization

Product Description: RING zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.01	0.99
Schizont	expressed	0.68	0.71
Gametocyte	possibly expressed	0.15	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1007300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.17 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJW9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_129764

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	43	16	42
disruptive	19	72	42	110
missense	17	70	41	94

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	79	28	45
disruptive	40	158	87	162
missense	32	140	74	119

PlasmoDB Total SNPs: 193

Non-coding: 139 | Synonymous: 29 | Nonsynonymous: 23 | Stop Codon: 2

Protein Information

Protein Length: 646 | Molecular Weight (kDa): 77.059

UniProt ID(s): Q8IJW9

PDB ID(s): None

Isoelectric Point: 8.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR029067	CDC48 domain 2-like superfamily
PFam	PF13639	Zinc finger, RING-type
Superfamily	SSF54585	CDC48 domain 2-like superfamily
Superfamily	SSF57850