About Gene List

PF3D7_1007400

Genome location: Pf3D7_10_v3:296,332..298,001(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.16 0.92
Trophozoite expressed 0.35 0.78
Schizont possibly expressed 0.63 0.65
Gametocyte not expressed 0.37 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1007400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.708 | MFS: -3.269 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJW8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533218

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 19 9 15
disruptive 4 22 10 50
missense 4 21 8 45

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 29 11 12
disruptive 12 54 27 62
missense 8 43 24 46

PlasmoDB Total SNPs: 120

Non-coding: 104 | Synonymous: 12 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 219 | Molecular Weight (kDa): 25.889

UniProt ID(s): Q8IJW8

PDB ID(s): None

Isoelectric Point: 8.38

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104