PF3D7_1007500

Genome location: Pf3D7_10_v3:298,184..298,889(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.19	0.90
Trophozoite	expressed	0.33	0.79
Schizont	possibly expressed	0.23	0.84
Gametocyte	not expressed	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1007500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.637 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1205700)

Relative Growth Rate: 1.03 ± 0.15
Confidence: 5.12

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1205700)

Modification: Disrupted | RMgm-3191

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3C5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532650

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	1	2	5
disruptive	1	19	9	22
missense	1	17	7	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	2	6	5
disruptive	4	47	17	36
missense	2	40	14	22

PlasmoDB Total SNPs: 48

Non-coding: 34 | Synonymous: 11 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 108 | Molecular Weight (kDa): 13.023

UniProt ID(s): C6S3C5

PDB ID(s): None

Isoelectric Point: 6.49

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A