About Gene List

PF3D7_1007800

Genome location: Pf3D7_10_v3:310,582..314,699(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.10 0.95
Trophozoite not expressed 0.10 0.95
Schizont not expressed 0.03 0.98
Gametocyte expressed 0.46 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1007800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.967 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJW5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112319

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 68 42 78
disruptive 31 218 127 215
missense 27 202 121 197

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 25 133 57 96
disruptive 72 465 165 304
missense 59 401 154 211

PlasmoDB Total SNPs: 195

Non-coding: 78 | Synonymous: 37 | Nonsynonymous: 80 | Stop Codon: 0

Protein Information

Protein Length: 1039 | Molecular Weight (kDa): 125.305

UniProt ID(s): Q8IJW5

PDB ID(s): None

Isoelectric Point: 8.75

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21