Product Description: eukaryotic translation initiation factor 3 subunit D, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.58 | 0.72 |
| Trophozoite | expressed | 0.77 | 0.58 |
| Schizont | expressed | 0.18 | 0.88 |
| Gametocyte | expressed | 0.52 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1007900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.993 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1206100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJW4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102252
Most Similar Human Ortholog: O15371
TM-align score: 0.68 | RMSD: 3.07
Seq Identity: 0.30 | Length: 396 / 543
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100353 | eukaryotic translation initiation factor 3 subunit D |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 34 | 22 | 46 |
| disruptive | 7 | 36 | 20 | 57 |
| missense | 7 | 35 | 19 | 52 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 78 | 26 | 42 |
| disruptive | 16 | 78 | 48 | 151 |
| missense | 14 | 69 | 37 | 101 |
PlasmoDB Total SNPs: 170
Non-coding: 139 | Synonymous: 28 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 543 | Molecular Weight (kDa): 63.11
UniProt ID(s): Q8IJW4
PDB ID(s): None
Isoelectric Point: 9.48
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007783 | Eukaryotic translation initiation factor 3 subunit D |
| PFam | PF05091 | Eukaryotic translation initiation factor 3 subunit D |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |