Product Description: histone deacetylase 2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.5.1.98 (Histone deacetylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Process | GO:0032958 | inositol phosphate biosynthetic process |
| Process | GO:0010468 | regulation of gene expression |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.19 | 0.50 |
| Trophozoite | expressed | 1.84 | 0.24 |
| Schizont | expressed | 1.77 | 0.30 |
| Gametocyte | not expressed | 1.16 | 0.44 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1008000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.138 | MFS: -2.924 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJW3
"Best" AlphaFill ligand hit: SHH (octanedioic acid hydroxyamide phenylamide, Local RMSD=0.03) with 1ZZ1 (Global RMSD=9.44)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.5.1.98 | histone deacetylase | EDTAPAOASAHAFOXPFK228MCP30shRNAsiRNAMS-275LAQ824MC1575MC1568... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9UBN7 | Histone deacetylase 6 | Homo sapiens | OrthoDB | VorinostatTubacinNK308Vorinostat... |
| Q969S8 | Polyamine deacetylase HDAC10 | Homo sapiens | OrthoDB | Trichostatin A (TSA)Triazole Ligand, 6aTriazole Ligand, 6bTriazole Ligand, 6c... |
| F8W4B7 | Histone deacetylase 6 [440-798] | OrthoDB | R-TSAS-TSATSATSA... | |
| Q8WUI4 | Histone deacetylase 7 | Homo sapiens | OrthoDB | CID10460379CID10435243US8685992, 14US8685986, 15... |
| P56524 | Histone deacetylase 4 | Homo sapiens | OrthoDB | Trichostatin A (TSA)NCH-31thiolate analogue, 13athiolate analogue, 15a... |
| Q9UKV0 | Histone deacetylase 9 | Homo sapiens | OrthoDB | CID10460379CID10435243US8685992, 14US8685986, 15... |
| Q9Z2V5 | Histone deacetylase 6 | Mus musculus | OrthoDB | Trichostatin A (TSA)NCH-31thiolate analogue, 13athiolate analogue, 15a... |
| F1QCV2 | Polyamine deacetylase HDAC10 | OrthoDB | CHEMBL2413999CHEMBL5181507CHEMBL5208700CHEMBL5208990... | |
| Q6P3E7 | Polyamine deacetylase HDAC10 | OrthoDB | CHEMBL4439518CHEMBL4447524 | |
| Q9UQL6 | Histone deacetylase 5 | Homo sapiens | OrthoDB | CID10460379CID10435243US8685992, 14US8685986, 15... |
Protein Length: 2379 | Molecular Weight (kDa): 282.227
UniProt ID(s): Q8IJW3
PDB ID(s): None
Isoelectric Point: 9.27
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000286 | Histone deacetylase family |
| InterPro | IPR005522 | Inositol polyphosphate kinase |
| InterPro | IPR023696 | Ureohydrolase domain superfamily |
| InterPro | IPR023801 | Histone deacetylase domain |
| PFam | PF00850 | Histone deacetylase domain |
| PFam | PF03770 | Inositol polyphosphate kinase |
| Superfamily | SSF52768 | Ureohydrolase domain superfamily |
| Superfamily | SSF56104 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 37 | 141 | 64 | 173 |
| disruptive | 132 | 399 | 221 | 471 |
| missense | 71 | 316 | 189 | 386 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 55 | 250 | 114 | 186 |
| disruptive | 233 | 779 | 336 | 673 |
| missense | 122 | 606 | 265 | 452 |
PlasmoDB Total SNPs: 486
Non-coding: 112 | Synonymous: 195 | Nonsynonymous: 178 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23123170 | A Plasmodium multi-domain protein possesses multiple inositol phosphate kinaseactivities. | Stritzke C, Nalaskowski MM, ..., Mayr GW | 10.1016/j.molbiopara.2012.10.005 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 25121747 | A Plasmodium falciparum histone deacetylase regulates antigenic variation andgametocyte conversion. | Coleman BI, Skillman KM, ..., Duraisingh MT | 10.1016/j.chom.2014.06.014 |
| 27864177 | Histone Deacetylase HDA-2 Regulates Trichoderma atroviride Growth, Conidiation, Blue Light Perception, and Oxidative Stress Responses | Osorio-Concepcion M, Cristobal-Mondragon GR, Gutierrez-Medina B, Casas-Flores S | 10.1128/AEM.02922-16 |
| 33523989 | Structural basis for the regulation of nucleosome recognition and HDAC activityby histone deacetylase assemblies | Lee JH, Bollschweiler D, Schafer T, Huber R | 10.1126/sciadv.abd4413 |
| 34843089 | A class I histone deacetylase HDA-2 is essential for embryonic development andsize regulation of fertilized eggs in Caenorhabditis elegans | Unno T, Takatsuka H, ..., Kubota Y | 10.1007/s13258-021-01195-9 |
| 30670606 | Trichoderma Histone Deacetylase HDA-2 Modulates Multiple Responses inArabidopsis | Estrada-Rivera M, Rebolledo-Prudencio OG, ..., Casas-Flores S | 10.1104/pp.18.01092 |
| 19659745 | Deletion of host histone acetyltransferases and deacetylases strongly affectsAgrobacterium-mediated transformation of Saccharomyces cerevisiae | Soltani J, van Heusden GP, Hooykaas PJ | 10.1111/j.1574-6968.2009.01723.x |