Product Description: PHD finger protein PHD1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000123 | histone acetyltransferase complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0035064 | methylated histone binding |
| Process | GO:0044409 | entry into host |
| Process | GO:0080182 | histone H3-K4 trimethylation |
| Process | GO:0043970 | histone H3-K9 acetylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.76 | 0.30 |
| Trophozoite | expressed | 1.90 | 0.22 |
| Schizont | expressed | 2.24 | 0.15 |
| Gametocyte | expressed | 1.31 | 0.39 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1008100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.825 | MFS: -2.082 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 58 | 235 | 116 | 296 |
| disruptive | 190 | 610 | 381 | 713 |
| missense | 121 | 519 | 332 | 607 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 88 | 465 | 180 | 273 |
| disruptive | 314 | 1211 | 489 | 904 |
| missense | 190 | 1006 | 411 | 680 |
PlasmoDB Total SNPs: 547
Non-coding: 132 | Synonymous: 212 | Nonsynonymous: 202 | Stop Codon: 1
Protein Length: 3853 | Molecular Weight (kDa): 453.006
UniProt ID(s): Q8IJW2
PDB ID(s): None
Isoelectric Point: 8.71
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001965 | Zinc finger, PHD-type |
| InterPro | IPR011011 | Zinc finger, FYVE/PHD-type |
| InterPro | IPR019786 | Zinc finger, PHD-type, conserved site |
| InterPro | IPR019787 | Zinc finger, PHD-finger |
| PFam | PF00628 | Zinc finger, PHD-finger |
| PFam | PF13771 | |
| Superfamily | SSF57903 | Zinc finger, FYVE/PHD-type |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31728527 | Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. | Hoeijmakers WAM, Miao J, ..., Bartfai R | 10.1093/nar/gkz1044 |
| 34403450 | A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion andvirulence in the malaria parasite Plasmodium falciparum. | Miao J, Wang C, ..., Cui L | 10.1371/journal.ppat.1009351 |
| 37008780 | Roxadustat (FG-4592) abated lipopolysaccharides-induced depressive-like symptomsvia PI3K signaling | Li A, Liu Z, ..., Li T | 10.3389/fnmol.2023.1048985 |