About Gene List

PF3D7_1008500

Genome location: Pf3D7_10_v3:349,785..355,986(+)

Genome classification: Core

Function and Localization

Product Description: protein GPR89, putative

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.36 0.82
Trophozoite possibly expressed 0.60 0.67
Schizont expressed 0.96 0.52
Gametocyte expressed 0.82 0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1008500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.954 | MFS: -1.971 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJV9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_157051

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 65 35 78
disruptive 80 174 89 200
missense 38 123 66 134

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 29 122 52 83
disruptive 138 348 148 320
missense 61 234 106 184

PlasmoDB Total SNPs: 394

Non-coding: 165 | Synonymous: 136 | Nonsynonymous: 93 | Stop Codon: 0

Protein Information

Protein Length: 1296 | Molecular Weight (kDa): 154.749

UniProt ID(s): Q8IJV9

PDB ID(s): None

Isoelectric Point: 6.92

Protein Domain Annotations:

Source Family ID Description
InterPro IPR015672 The Golgi pH regulator/GPCR-type G protein
InterPro IPR025969 Abscisic acid G-protein coupled receptor-like domain
PFam PF12430 Abscisic acid G-protein coupled receptor-like domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097