PF3D7_1008600

Genome location: Pf3D7_10_v3:357,345..358,463(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger (CCCH type) protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.05	0.97
Gametocyte	expressed	0.21	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1008600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.569 | MFS: -2.322 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1206800)

Modification: Disrupted | RMgm-4920

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJV8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533063

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	25	20	31
disruptive	9	67	38	83
missense	7	45	30	63

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	64	14	26
disruptive	36	134	61	168
missense	18	99	51	82

PlasmoDB Total SNPs: 45

Non-coding: 0 | Synonymous: 30 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 372 | Molecular Weight (kDa): 43.991

UniProt ID(s): Q8IJV8

PDB ID(s): None

Isoelectric Point: 6.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000571	Zinc finger, CCCH-type
InterPro	IPR036855	Zinc finger, CCCH-type superfamily
PFam	PF00642	Zinc finger, CCCH-type
PFam	PF14608
Superfamily	SSF90229	Zinc finger, CCCH-type superfamily