Product Description: nucleolar protein 5, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031428 | box C/D RNP complex |
| Component | GO:0005730 | nucleolus |
| Component | GO:0005634 | nucleus |
| Component | GO:0032040 | small-subunit processome |
| Function | GO:0003723 | RNA binding |
| Function | GO:0030515 | snoRNA binding |
| Process | GO:0006364 | rRNA processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.40 | 0.39 |
| Trophozoite | expressed | 0.80 | 0.59 |
| Schizont | expressed | 0.20 | 0.89 |
| Gametocyte | expressed | 0.70 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1008800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -3.111 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJV7
"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=1.68) with 3NMU (Global RMSD=3.64)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101575
Most Similar Human Ortholog: H7BZ72
TM-align score: 0.88 | RMSD: 2.06
Seq Identity: 0.51 | Length: 177 / 469
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000055044 | NOP58 ribonucleoprotein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 29 | 13 | 25 |
| disruptive | 2 | 17 | 18 | 56 |
| missense | 2 | 17 | 18 | 51 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 56 | 21 | 39 |
| disruptive | 5 | 54 | 45 | 122 |
| missense | 3 | 49 | 34 | 80 |
PlasmoDB Total SNPs: 87
Non-coding: 76 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 469 | Molecular Weight (kDa): 53.41
UniProt ID(s): Q8IJV7
PDB ID(s): None
Isoelectric Point: 10.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002687 | Nop domain |
| InterPro | IPR012974 | NOP5, N-terminal |
| InterPro | IPR012976 | NOSIC |
| InterPro | IPR036070 | Nop domain superfamily |
| PFam | PF01798 | Nop domain |
| PFam | PF08156 | NOP5, N-terminal |
| Superfamily | SSF89124 | Nop domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20696894 | Clustering of dispersed ribosomal DNA and its role in gene regulation andchromosome-end associations in malaria parasites. | Mancio-Silva L, Zhang Q, Scheidig-Benatar C, Scherf A | 10.1073/pnas.1001045107 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 20797632 | A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58 | Westman BJ, Verheggen C, ..., Lamond AI | 10.1016/j.molcel.2010.07.025 |
| 10788506 | Multiple growth factor induction of a murine early response gene that complementsa lethal defect in yeast ribosome biogenesis | Nelson SA, Aris JP, Patel BK, LaRochelle WJ | 10.1074/jbc.275.18.13835 |