Product Description: adenylate kinase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.4.3 (Adenylate kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0004017 | adenylate kinase activity |
| Process | GO:0006091 | generation of precursor metabolites and energy |
| Process | GO:0009132 | nucleoside diphosphate metabolic process |
| Process | GO:0006163 | purine nucleotide metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.52 | 0.76 |
| Trophozoite | expressed | 1.14 | 0.43 |
| Schizont | expressed | 0.28 | 0.83 |
| Gametocyte | expressed | 0.32 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1008900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.385 | MFS: -3.482 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1207200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJV6
"Best" AlphaFill ligand hit: AP5 (bis(adenosine)-5'-pentaphosphate, Local RMSD=0.18) with 5YCF (Global RMSD=5.07)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.4.3 | adenylate kinase | BRENDA SOAP query unsuccessful |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P29410 | Adenylate kinase 2, mitochondrial | OrthoDB | CHEMBL605639CHEMBL604399CHEMBL605639CHEMBL604399 |
Ortholog Group (OrthoMCL): OG6_100712
Most Similar Human Ortholog: F8W1A4
TM-align score: 0.93 | RMSD: 1.42
Seq Identity: 0.47 | Length: 222 / 242
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000004455 | adenylate kinase 2 |
Protein Length: 242 | Molecular Weight (kDa): 27.611
PDB ID(s): None
Isoelectric Point: 9.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000850 | Adenylate kinase/UMP-CMP kinase |
| InterPro | IPR006259 | Adenylate kinase subfamily |
| InterPro | IPR007862 | Adenylate kinase, active site lid domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR033690 | Adenylate kinase, conserved site |
| PFam | PF00406 | Adenylate kinase, active site lid domain |
| PFam | PF05191 | |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 13 | 6 | 21 |
| disruptive | 0 | 10 | 0 | 21 |
| missense | 0 | 10 | 0 | 18 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 30 | 6 | 22 |
| disruptive | 5 | 25 | 11 | 49 |
| missense | 1 | 18 | 11 | 36 |
PlasmoDB Total SNPs: 148
Non-coding: 139 | Synonymous: 8 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15478799 | Adenylate kinase and GTP:AMP phosphotransferase of the malarial parasitePlasmodium falciparum. Central players in cellular energy metabolism. | Ulschmid JK, Rahlfs S, Schirmer RH, Becker K | 10.1016/j.molbiopara.2004.04.001 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 22819813 | Subcellular localization of adenylate kinases in Plasmodium falciparum. | Ma J, Rahlfs S, ..., Becker K | 10.1016/j.febslet.2012.07.013 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |