PF3D7_1009100

Genome location: Pf3D7_10_v3:372,519..374,072(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: MSWYSLLTLLLVSSILYIQHVTC

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	expressed	0.31	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1009100

Resistome Missense Mutations: K452I

Resistome Compounds with Missense Mutations: MMV011895

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.174 | MFS: -2.779 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1207400)

Relative Growth Rate: 1.02 ± 0.10
Confidence: 6.06

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1207400)

Modification: Disrupted | RMgm-3199

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJV4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533415

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	34	16	35
disruptive	27	111	52	126
missense	17	94	47	105

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	65	28	38
disruptive	52	203	81	189
missense	26	169	67	129

PlasmoDB Total SNPs: 38

Non-coding: 0 | Synonymous: 17 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 517 | Molecular Weight (kDa): 63.129

UniProt ID(s): Q8IJV4

PDB ID(s): None

Isoelectric Point: 10.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097