PF3D7_1009200

Genome location: Pf3D7_10_v3:374,378..377,772(+)

Genome classification: Core

Function and Localization

Product Description: ribonuclease, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.13	0.93
Trophozoite	expressed	0.12	0.92
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.28	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1009200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.34 | MFS: -2.68 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1207500)

Relative Growth Rate: 0.27 ± 0.43
Confidence: 3.07

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJV3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104387

Most Similar Human Ortholog: G3XAN1

TM-align score: 0.76 | RMSD: 3.03

Seq Identity: 0.21 | Length: 435 / 915

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000104299	integrator complex subunit 9

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	64	31	81
disruptive	36	125	83	152
missense	24	98	73	124

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	133	56	69
disruptive	70	253	134	271
missense	42	195	101	182

PlasmoDB Total SNPs: 114

Non-coding: 51 | Synonymous: 30 | Nonsynonymous: 33 | Stop Codon: 0

Protein Information

Protein Length: 915 | Molecular Weight (kDa): 106.458

UniProt ID(s): Q8IJV3

PDB ID(s): None

Isoelectric Point: 6.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027074	Integrator complex subunit 9
InterPro	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
PFam	N/A	N/A
Superfamily	SSF56281	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like