About Gene List

PF3D7_1009400 (ZNF2)

Genome location: Pf3D7_10_v3:381,136..382,816(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.12 0.94
Trophozoite expressed 0.18 0.88
Schizont expressed 0.06 0.96
Gametocyte expressed 0.16 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1009400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.724 | MFS: -2.005 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1207700)

  • Relative Growth Rate: 0.97 ± 0.11
  • Confidence: 5.79

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1207700)

Modification: Disrupted | RMgm-3201

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJV1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102795

Most Similar Human Ortholog: J3QS27

TM-align score: 0.77 | RMSD: 1.54

Seq Identity: 0.48 | Length: 44 / 362

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000010244 zinc finger protein 207

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 19 14 17
disruptive 10 41 18 48
missense 8 40 17 44

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 36 13 13
disruptive 17 68 37 89
missense 15 64 36 61

PlasmoDB Total SNPs: 114

Non-coding: 96 | Synonymous: 11 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 362 | Molecular Weight (kDa): 41.329

UniProt ID(s): Q8IJV1

PDB ID(s): None

Isoelectric Point: 9.66

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013087 Zinc finger C2H2-type
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108