Product Description: protein phosphatase PPM10, putative
SignalP Peptide: MIYTRVYCIFIILLLNNMLITHN
# Transmembrane Domains: 0
EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.17 | 0.92 |
| Trophozoite | expressed | 0.86 | 0.55 |
| Schizont | possibly expressed | 0.06 | 0.96 |
| Gametocyte | possibly expressed | 0.62 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1009600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.445 | MFS: -2.495 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1207900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1207900)
Modification: Disrupted | RMgm-3203
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZY63
"Best" AlphaFill ligand hit: POG (heptapropylene glycol, Local RMSD=1.43) with 6AE9 (Global RMSD=2.56)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.3.16 | protein-serine/threonine phosphatase | ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100742
Most Similar Human Ortholog: Q8NI37
TM-align score: 0.74 | RMSD: 1.68
Seq Identity: 0.30 | Length: 236 / 488
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000196850 | protein phosphatase targeting COQ7 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 23 | 15 | 29 |
| disruptive | 30 | 32 | 19 | 51 |
| missense | 10 | 19 | 15 | 38 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 45 | 21 | 28 |
| disruptive | 39 | 79 | 36 | 98 |
| missense | 14 | 46 | 29 | 69 |
PlasmoDB Total SNPs: 71
Non-coding: 11 | Synonymous: 37 | Nonsynonymous: 23 | Stop Codon: 0
Protein Length: 488 | Molecular Weight (kDa): 56.857
UniProt ID(s): A0A143ZY63
PDB ID(s): None
Isoelectric Point: 9.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001932 | PPM-type phosphatase domain |
| InterPro | IPR036457 | PPM-type phosphatase domain superfamily |
| InterPro | IPR039123 | Protein phosphatase 2C |
| PFam | PF07228 | PPM-type phosphatase domain |
| Superfamily | SSF81606 | PPM-type phosphatase domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |