PF3D7_1009800

Genome location: Pf3D7_10_v3:393,189..398,429(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.81	0.63
Trophozoite	expressed	0.60	0.66
Schizont	expressed	0.37	0.77
Gametocyte	expressed	0.73	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1009800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.023 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1208100)

Relative Growth Rate: 0.08 ± 0.14
Confidence: 5.33

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJU7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533477

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	71	48	88
disruptive	82	226	138	322
missense	55	195	123	280

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	31	147	65	101
disruptive	146	508	217	431
missense	96	425	162	288

PlasmoDB Total SNPs: 308

Non-coding: 122 | Synonymous: 70 | Nonsynonymous: 114 | Stop Codon: 2

Protein Information

Protein Length: 1345 | Molecular Weight (kDa): 162.366

UniProt ID(s): Q8IJU7

PDB ID(s): None

Isoelectric Point: 8.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A