PF3D7_1009900

Genome location: Pf3D7_10_v3:399,176..402,012(+)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Function	GO:0051082	unfolded protein binding
Process	GO:0006612	protein targeting to membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.28	0.86
Trophozoite	expressed	0.31	0.81
Schizont	expressed	0.11	0.93
Gametocyte	expressed	0.51	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1009900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.089 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJU6

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=6.85) with 6VVE (Global RMSD=10.77)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532663

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	43	20	37
disruptive	22	85	53	106
missense	16	67	49	90

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	71	26	42
disruptive	37	185	93	191
missense	27	139	75	133

PlasmoDB Total SNPs: 97

Non-coding: 29 | Synonymous: 49 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 779 | Molecular Weight (kDa): 93.471

UniProt ID(s): Q8IJU6

PDB ID(s): None

Isoelectric Point: 8.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004138	HSV U79 / HCMV P34
InterPro	IPR016641	Nascent polypeptide-associated complex subunit alpha
PFam	PF03064	HSV U79 / HCMV P34
Superfamily	N/A	N/A