Product Description: ribosomal protein L43, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.29 | 0.85 |
| Trophozoite | expressed | 0.84 | 0.54 |
| Schizont | expressed | 0.30 | 0.81 |
| Gametocyte | expressed | 0.55 | 0.68 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1010000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.146 | MFS: -3.246 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1208400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJU5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103158
Most Similar Human Ortholog: B1AL05
TM-align score: 0.60 | RMSD: 2.53
Seq Identity: 0.22 | Length: 124 / 213
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000055950 | mitochondrial ribosomal protein L43 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 14 | 4 | 10 |
| disruptive | 0 | 3 | 3 | 18 |
| missense | 0 | 3 | 3 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 17 | 13 | 19 |
| disruptive | 3 | 14 | 16 | 32 |
| missense | 0 | 10 | 15 | 26 |
PlasmoDB Total SNPs: 107
Non-coding: 101 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 213 | Molecular Weight (kDa): 25.457
UniProt ID(s): Q8IJU5
PDB ID(s): None
Isoelectric Point: 9.8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007741 | Ribosomal protein/NADH dehydrogenase domain |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| InterPro | IPR039927 | 39S ribosomal protein L43/54S ribosomal protein L51 |
| PFam | PF05047 | Ribosomal protein/NADH dehydrogenase domain |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |