About Gene List

PF3D7_1010300 (SDH4)

Genome location: Pf3D7_10_v3:412,469..415,659(+)

Genome classification: Core

Function and Localization

Product Description: succinate dehydrogenase subunit 4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: 1.3.5.1 (Succinate dehydrogenase (quinone))

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 2.39 0.23
Trophozoite expressed 0.89 0.55
Schizont expressed 1.29 0.38
Gametocyte expressed 0.41 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1010300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.129 | MFS: -3.165 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1208700)

  • Relative Growth Rate: 0.56 ± 0.15
  • Confidence: 5.23

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1208700)

Modification: Disrupted | RMgm-3209

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJU2

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
1.3.5.1 succinate dehydrogenase oxalateMaleatefumaratemalonaterotenonecarboxinsiccaninboscalidfenfurammepronilclozapinebenodanil...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532895

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 204

Non-coding: 186 | Synonymous: 15 | Nonsynonymous: 2 | Stop Codon: 1

Protein Information

Protein Length: 118 | Molecular Weight (kDa): 13.737

UniProt ID(s): Q8IJU2

PDB ID(s): None

Isoelectric Point: 10.84

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
29912874 Yeast Cth2 protein represses the translation of ARE-containing mRNAs in responseto iron deficiency Ramos-Alonso L, Romero AM, ..., Martinez-Pastor MT 10.1371/journal.pgen.1007476
25328978 Instability of succinate dehydrogenase in SDHD polymorphism connects reactiveoxygen species production to nuclear and mitochondrial genomic mutations inyeast Chang YL, Hsieh MH, ..., Teng SC 10.1089/ars.2014.5966
22277779 Identification and characterization of genes related to the production of organicacids in yeast Yoshida S, Yokoyama A 10.1016/j.jbiosc.2011.12.017