PF3D7_1010400

Genome location: Pf3D7_10_v3:415,404..417,471(-)

Genome classification: Core

Function and Localization

Product Description: MORN repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.7.1.68 (1-phosphatidylinositol-4-phosphate 5-kinase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.05	0.97
Trophozoite	possibly expressed	0.02	0.99
Schizont	expressed	0.11	0.93
Gametocyte	expressed	0.85	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1010400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.937 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJU1

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
2.7.1.68	1-phosphatidylinositol-4-phosphate 5-kinase	ATPADPNEMEDTAPCMBGSSGZnSO4Cutsumheparincysteinesperminequercetin...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_124596

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	21	12	24
disruptive	24	47	31	69
missense	9	32	22	53

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	36	19	19
disruptive	39	117	45	96
missense	14	85	31	66

PlasmoDB Total SNPs: 221

Non-coding: 129 | Synonymous: 43 | Nonsynonymous: 49 | Stop Codon: 0

Protein Information

Protein Length: 364 | Molecular Weight (kDa): 42.829

UniProt ID(s): Q8IJU1

PDB ID(s): None

Isoelectric Point: 6.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003409	MORN motif
PFam	PF02493	MORN motif
Superfamily	SSF82185	N/A