PF3D7_1010500

Genome location: Pf3D7_10_v3:417,705..419,318(+)

Genome classification: Core

Function and Localization

Product Description: ankyrin-repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.01	0.99
Trophozoite	possibly expressed	0.00	1.00
Schizont	expressed	0.05	0.97
Gametocyte	expressed	0.50	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1010500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.399 | MFS: -2.544 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJU0

"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=0.10) with 3Q9U (Global RMSD=1.91)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105922

Most Similar Human Ortholog: Q96KQ7

TM-align score: 0.88 | RMSD: 2.06

Seq Identity: 0.18 | Length: 166 / 169

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000181090	euchromatic histone lysine methyltransferase 1
ENSG00000204371	euchromatic histone lysine methyltransferase 2
ENSG00000206376	euchromatic histone lysine methyltransferase 2
ENSG00000224143	euchromatic histone lysine methyltransferase 2
ENSG00000227333	euchromatic histone lysine methyltransferase 2
ENSG00000232045	euchromatic histone lysine methyltransferase 2
ENSG00000236759	euchromatic histone lysine methyltransferase 2
ENSG00000238134	euchromatic histone lysine methyltransferase 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	5	8	9
disruptive	0	11	4	23
missense	0	11	4	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	19	11	11
disruptive	2	25	18	51
missense	2	18	14	32

PlasmoDB Total SNPs: 131

Non-coding: 127 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 169 | Molecular Weight (kDa): 19.275

UniProt ID(s): Q8IJU0

PDB ID(s): None

Isoelectric Point: 9.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR036770	Ankyrin repeat-containing domain superfamily
PFam	PF12796	Ankyrin repeat-containing domain
PFam	PF13606	Ankyrin repeat
Superfamily	SSF48403	Ankyrin repeat-containing domain superfamily