Genome location: Pf3D7_10_v3:419,366..422,371(-)
Genome classification: Core
Product Description: eukaryotic translation initiation factor 2 subunit beta
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005850 | eukaryotic translation initiation factor 2 complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0003743 | translation initiation factor activity |
| Function | GO:0031369 | translation initiation factor binding |
| Process | GO:0001732 | formation of cytoplasmic translation initiation complex |
| Process | GO:0001731 | formation of translation preinitiation complex |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.25 | 0.87 |
| Trophozoite | expressed | 0.53 | 0.69 |
| Schizont | expressed | 0.10 | 0.93 |
| Gametocyte | expressed | 0.16 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1010600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.138 | MFS: -2.771 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJT9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101265
Most Similar Human Ortholog: P20042
TM-align score: 0.69 | RMSD: 1.91
Seq Identity: 0.46 | Length: 164 / 222
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000125977 | eukaryotic translation initiation factor 2 subunit beta |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 168
Non-coding: 159 | Synonymous: 4 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 222 | Molecular Weight (kDa): 25.322
UniProt ID(s): Q8IJT9
PDB ID(s): None
Isoelectric Point: 9.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002735 | Translation initiation factor IF2/IF5 |
| InterPro | IPR016189 | Translation initiation factor IF2/IF5, N-terminal |
| InterPro | IPR016190 | Translation initiation factor IF2/IF5, zinc-binding |
| PFam | PF01873 | Translation initiation factor IF2/IF5 |
| Superfamily | SSF100966 | Translation initiation factor IF2/IF5, N-terminal |
| Superfamily | SSF75689 | Translation initiation factor IF2/IF5, zinc-binding |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27303372 | Identification of Plasmodium falciparum Translation Initiation eIF2beta Subunit:Direct Interaction with Protein Phosphatase Type 1. | Tellier G, Lenne A, ..., Khalife J | 10.3389/fmicb.2016.00777 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |