Product Description: dolichyl-phosphate-mannose--protein mannosyltransferase, putative
SignalP Peptide: MINNNLFVFFLLSFFLSKICTC
# Transmembrane Domains: 0
EC Numbers: 2.4.1.109 (Dolichyl-phosphate-mannose--protein mannosyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.30 | 0.85 |
| Trophozoite | expressed | 0.56 | 0.67 |
| Schizont | expressed | 0.18 | 0.88 |
| Gametocyte | expressed | 0.78 | 0.57 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1010700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.572 | MFS: -2.477 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJT8
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.4.1.109 | dolichyl-phosphate-mannose-protein mannosyltransferase | CuSO4glycerolchymotrypsinphosphatidylinositol5-[[3,4-bis(phenylmethoxy)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid5-[[3,4-bis(phenylmethoxy)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidine acetic acid5-[[(3-(1-phenyl-2-hydroxy)ethoxy)-4-(2-phenylethoxy)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid5-[[(3-(1-phenyl-2-hydroxy)ethoxy)-4-(2-phenylethoxy)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidine acetic acid |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102590
Most Similar Human Ortholog: K7ELI9
TM-align score: 0.88 | RMSD: 1.96
Seq Identity: 0.29 | Length: 104 / 223
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000128228 | stromal cell derived factor 2 like 1 |
| ENSG00000132581 | stromal cell derived factor 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 16 | 7 | 10 |
| disruptive | 0 | 4 | 8 | 13 |
| missense | 0 | 4 | 8 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 25 | 5 | 12 |
| disruptive | 2 | 19 | 16 | 32 |
| missense | 0 | 16 | 13 | 21 |
PlasmoDB Total SNPs: 198
Non-coding: 186 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 2
Protein Length: 223 | Molecular Weight (kDa): 25.678
UniProt ID(s): Q8IJT8
PDB ID(s): None
Isoelectric Point: 6.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036300 | Mir domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF82109 | Mir domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |