Product Description: 50S ribosomal protein L22, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0015934 | large ribosomal subunit |
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0042255 | ribosome assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.12 | 0.92 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | possibly expressed | 0.19 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1010800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.175 | MFS: -3.286 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJT7
"Best" AlphaFill ligand hit: YPG ([3r,4r]-4-guanin-9-yl-3-((s)-2-hydroxy-2-phosphonoethyl)oxy-1-n-(phosphonopropionyl)pyrrolidine, Local RMSD=1.60) with 6BO7 (Global RMSD=15.13)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 16 | 8 | 23 |
| disruptive | 6 | 13 | 11 | 23 |
| missense | 6 | 13 | 11 | 19 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 34 | 9 | 19 |
| disruptive | 9 | 33 | 18 | 58 |
| missense | 9 | 30 | 15 | 45 |
PlasmoDB Total SNPs: 118
Non-coding: 102 | Synonymous: 12 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 299 | Molecular Weight (kDa): 36.938
UniProt ID(s): Q8IJT7
PDB ID(s): None
Isoelectric Point: 10.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001063 | Ribosomal protein L22/L17 |
| InterPro | IPR005727 | Ribosomal protein L22, bacterial/chloroplast-type |
| InterPro | IPR036394 | Ribosomal protein L22/L17 superfamily |
| PFam | PF00237 | Ribosomal protein L22/L17 |
| Superfamily | SSF54843 | Ribosomal protein L22/L17 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |