Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | possibly expressed | 0.19 | 0.91 |
Trophozoite | possibly expressed | 0.39 | 0.77 |
Schizont | possibly expressed | 0.06 | 0.96 |
Gametocyte | not expressed | 0.71 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1010900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.14 | MFS: -2.819 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1209300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJT6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 1 | 16 | 14 | 34 |
disruptive | 7 | 37 | 21 | 67 |
missense | 5 | 34 | 21 | 64 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 44 | 16 | 33 |
disruptive | 21 | 87 | 42 | 103 |
missense | 15 | 79 | 35 | 72 |
PlasmoDB Total SNPs: 191
Non-coding: 148 | Synonymous: 32 | Nonsynonymous: 10 | Stop Codon: 1
Protein Length: 349 | Molecular Weight (kDa): 41.364
UniProt ID(s): Q8IJT6
PDB ID(s): None
Isoelectric Point: 8.7
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |