About Gene List

PF3D7_1011000 (ISP1)

Genome location: Pf3D7_10_v3:428,682..430,858(-)

Genome classification: Core

Function and Localization

Product Description: inner membrane complex sub-compartment protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045177 apical part of cell
Component GO:0005829 cytosol
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite possibly expressed 0.15 0.90
Schizont possibly expressed 0.23 0.85
Gametocyte not expressed 0.51 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1011000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.513 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_1212600)

Modification: Tagged | RMgm-4899

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJT5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130933

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 1
disruptive 0 1 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 1 0 0
disruptive 0 1 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 97

Non-coding: 95 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 144 | Molecular Weight (kDa): 16.585

UniProt ID(s): Q8IJT5

PDB ID(s): None

Isoelectric Point: 7.01

Protein Domain Annotations:

Source Family ID Description
InterPro IPR041316 ISP1 C-terminal
PFam PF18161 ISP1 C-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
22389454 Evolution and architecture of the inner membrane complex in asexual and sexualstages of the malaria parasite. Kono M, Herrmann S, ..., Gilberger TW 10.1093/molbev/mss081
24244852 Unique apicomplexan IMC sub-compartment proteins are early markers for apicalpolarity in the malaria parasite. Poulin B, Patzewitz EM, ..., Tewari R 10.1242/bio.20136163